Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans.

ABSTRACT: Genome-wide association studies (GWAS) in admixed populations such as African Americans (AA) have limited sample sizes, resulting in poor performance of polygenic risk scores (PRS). Based on the observations that many disease-causing genes are shared between AA and European ancestry (EA) populations, and some disease-causing variants are located within the boundaries of these genes, we proposed a novel gene-based PRS framework (PRS_gene) by using variants located within disease-associated genes. Using the AA GWAS of alcohol use disorder (AUD) from the Million Veteran Program and the EA GWAS of problematic alcohol use as the discovery GWAS, we identified 858 variants from 410 genes that were AUD-related in both AA and EA. PRS_gene calculated using these variants were sig

SUBMITTER: Lai D 

PROVIDER: S-EPMC9256707 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature