Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution.

ABSTRACT:

Background

We previously reported a relationship between air pollutants and increased risk of pediatric-onset multiple sclerosis (POMS). Ozone is an air pollutant that may play a role in multiple sclerosis (MS) pathoetiology. CD86 is the only non-HLA gene associated with POMS for which expression on antigen-presenting cells (APCs) is changed in response to ozone exposure.

Objectives

To examine the association between county-level ozone and POMS, and the interactions between ozone pollution, CD86, and HLA-DRB1*15, the strongest genetic variant associated with POMS.

Methods

Cases and controls were enrolled in the Environmental and Genetic Risk Factors for Pediatric MS study of the US Network of Pediatric MS Centers. County-level-modeled ozone

SUBMITTER: Ziaei A 

PROVIDER: S-EPMC9256753 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature