Cortical lesion hotspots and association of subpial lesions with disability in multiple sclerosis.

ABSTRACT:

Background

Dramatic improvements in visualization of cortical (especially subpial) multiple sclerosis (MS) lesions allow assessment of impact on clinical course.

Objective

Characterize cortical lesions by 7 tesla (T) T₂^*-/T₁-weighted magnetic resonance imaging (MRI); determine relationship with other MS pathology and contribution to disability.

Methods

Sixty-four adults with MS (45 relapsing-remitting/19 progressive) underwent 3 T brain/spine MRI, 7 T brain MRI, and clinical testing.

Results

Cortical lesions were found in 94% (progressive: median 56/range 2-203; relapsing-remitting: 15/0-168; p = 0.004). Lesion distribution across 50 cortical regions was nonuniform (p = 0.006), with highest lesion burden in supplem

SUBMITTER: Beck ES 

PROVIDER: S-EPMC9256754 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature