Traceless Benzylic C-H Amination via Bifunctional N-Aminopyridinium Intermediates.

ABSTRACT: C-H amination reactions provide the opportunity to streamline the synthesis of nitrogen-containing organic small molecules. The impact of intermolecular C-H amination methods, however, is currently limited the frequent requirement for the amine precursors to bear activating groups, such as N-sulfonyl substituents, that are both challenging to remove and not useful synthetic handles for subsequent derivatization. Here, we introduce traceless nitrogen activation for C-H amination-which enables application of selective C-H amination chemistry to the preparation of diverse N-functionalized products-via sequential benzylic C-H N-aminopyridylation followed by Ni-catalyzed C-N cross-coupling with aryl boronic acids. Unlike many C-H amination reactions that provide access to protected amines, the

SUBMITTER: Roychowdhury P 

PROVIDER: S-EPMC9256810 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature