Reverse Triggering: An Introduction to Diagnosis, Management, and Pharmacologic Implications.

ABSTRACT: Reverse triggering is an underdiagnosed form of patient-ventilator asynchrony in which a passive ventilator-delivered breath triggers a neural response resulting in involuntary patient effort and diaphragmatic contraction. Reverse triggering may significantly impact patient outcomes, and the unique physiology underscores critical potential implications for drug-device-patient interactions. The purpose of this review is to summarize what is known of reverse triggering and its pharmacotherapeutic consequences, with a particular focus on describing reported cases, physiology, historical context, epidemiology, and management. The PubMed database was searched for publications that reported patients presenting with reverse triggering. The current body of evidence suggests that deep sedation may

SUBMITTER: Murray B 

PROVIDER: S-EPMC9256988 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature