The Role of Vascular-Immune Interactions in Modulating Chemotherapy Induced Neuropathic Pain.

ABSTRACT: Chemotherapy causes sensory disturbances in cancer patients that results in neuropathies and pain. As cancer survivorships has dramatically increased over the past 10 years, pain management of these patients is becoming clinically more important. Current analgesic strategies are mainly ineffective and long-term use is associated with severe side effects. The issue being that common analgesic strategies are based on ubiquitous pain mediator pathways, so when applied to clinically diverse neuropathic pain and neurological conditions, are unsuccessful. This is principally due to the lack of understanding of the driving forces that lead to chemotherapy induced neuropathies. It is well documented that chemotherapy causes sensory neurodegeneration through axonal atrophy and intraepidermal fibre

SUBMITTER: Valentine T 

PROVIDER: S-EPMC9257211 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature