Distinct Contribution of Global and Regional Angiotensin II Type 1a Receptor Inactivation to Amelioration of Aortopathy in Tgfbr1 ^M318R/+ Mice.

ABSTRACT: Angiotensin II (Ang II) type 1 receptor (AT1R) signaling controls both physiological and pathogenetic responses in the vasculature. In mouse models of Loeys-Dietz syndrome (LDS), a hereditary disorder characterized by aggressive aortic aneurysms, treatment with angiotensin receptor blockers (ARBs) prevents aortic root dilation and associated histological alterations. In this study we use germline and conditional genetic inactivation of Agtr1a (coding for the AT1a receptor) to assess the effect of systemic and localized AT1R signaling attenuation on aortic disease in a mouse model of LDS (Tgfbr1 ^M318R/+). Aortic diameters and histological features were examined in control and Tgfbr1 ^M318R/+ mice with either germline or Mef2C

SUBMITTER: Bramel EE 

PROVIDER: S-EPMC9257222 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature