Fetal DNA Causes Sex-Specific Inflammation From Human Fetal Membranes.

ABSTRACT: Inflammation is central to the mechanisms of parturition, but the lack of understanding of how it is controlled in normal parturition hampers our ability to understand how it may diverge resulting in preterm birth. Cell-free fetal DNA is found in the amniotic fluid, and it is thought to be able to activate inflammation as a danger-associated molecular pattern. Although its levels increases with gestational age, its effect has not been studied on the human fetal membranes. Thus, the aim of this study was to determine if the fetal DNA can trigger inflammation in the human fetal membranes and, thus, potentially contribute to the inflammatory load. Isolated human amniotic epithelial cells and fetal membrane explants were treated apically with fetal DNA causing the translocation of NF-KB into t

SUBMITTER: Saito Reis CA 

PROVIDER: S-EPMC9257279 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature