Histological changes associated with laser interstitial thermal therapy for radiation necrosis: illustrative cases.

ABSTRACT:

Background

Patients with lung cancer and melanoma remain the two largest groups to develop brain metastases. Immunotherapy has been approved for treatment of stage IV disease in both groups. Many of these patients are additionally treated with stereotactic radiosurgery for their brain metastases during ongoing immunotherapy. Use of immunotherapy has been reported to increase the rates of radiation necrosis (RN) after radiosurgery, causing neurological compromise due to growth of the enhancing lesion as well as worsening of associated cerebral edema.

Observations

Laser interstitial thermal therapy (LITT) is a surgical approach that has been shown effective in the management of RN, especially given its efficacy in early reduction of perilesional edema. However, little remains

SUBMITTER: Fomchenko EI 

PROVIDER: S-EPMC9257400 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature