Discordant Spirometry and Impulse Oscillometry Assessments in the Diagnosis of Small Airway Dysfunction.

ABSTRACT: Background and objective: Spirometry is commonly used to assess small airway dysfunction (SAD). Impulse oscillometry (IOS) can complement spirometry. However, discordant spirometry and IOS in the diagnosis of SAD were not uncommon. We examined the association between spirometry and IOS within a large cohort of subjects to identify variables that may explain discordant spirometry and IOS findings. Methods: 1,836 subjects from the ECOPD cohort underwent questionnaires, symptom scores, spirometry, and IOS, and 1,318 subjects were examined by CT. We assessed SAD with R₅-R₂₀ > the upper limit of normal (ULN) by IOS and two of the three spirometry indexes (maximal mid-expiratory flow (MMEF), forced expiratory flow (FEF)_50%, and FEF_75%) <

SUBMITTER: Lu L 

PROVIDER: S-EPMC9257410 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature