MIL-53-based homochiral metal-organic framework as a stationary phase for open-tubular capillary electrochromatography.

ABSTRACT: Homochiral metal-organic frameworks (MOFs) have attracted considerable attention in many fields of research, such as chiral catalysis and chiral chromatography. However, only few homochiral MOFs can be effectively used in capillary electrochromatography (CEC) and their performances are far from adequate. In this study, we successfully synthesized achiral nanocrystalline MIL-53. A facile post-synthetic modification strategy was then implemented to functionalize the product, yielding a homochiral MOF: l-His-NH-MIL-53. This MOF was then employed as a chiral coating in open-tubular CEC mode (OT-CEC), and, as such, it exhibited high enantioselectivities for several racemic drugs. The homochiral MOF and the fabricated capillary coating were systematically characterized using transmission electro

SUBMITTER: Sun X 

PROVIDER: S-EPMC9257441 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature