Serum metabolomic signatures of plant-based diets and incident chronic kidney disease.

ABSTRACT:

Background

Greater adherence to plant-based diets is associated with a lower risk of incident chronic kidney disease (CKD). Metabolomics can help identify blood biomarkers of plant-based diets and enhance understanding of underlying mechanisms.

Objectives

Using untargeted metabolomics, we aimed to identify metabolites associated with 4 plant-based diet indices (PDIs) (overall PDI, provegetarian diet, healthful PDI, and unhealthful PDI) and incident CKD in 2 subgroups within the Atherosclerosis Risk in Communities study.

Methods

We calculated 4 PDIs based on participants' responses on an FFQ. We used multivariable linear regression to examine the association between 4 PDIs and 374 individual metabolites, adjusting for confounders. We used Cox proportional hazards regre

SUBMITTER: Kim H 

PROVIDER: S-EPMC9257476 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature