Low- versus Mid-frequency Raman Spectroscopy for in Situ Analysis of Crystallization in Slurries.

ABSTRACT: Slurry studies are useful for exhaustive polymorph and solid-state stability screening of drug compounds. Raman spectroscopy is convenient for monitoring crystallization in such slurries, as the measurements can be performed in situ even in aqueous environments. While the mid-frequency region (400-4000 cm^-1) is dominated by intramolecular vibrations and has traditionally been used for such studies, the low-frequency spectral region (<200 cm^-1) probes solid-state related lattice vibrations and is potentially more valuable for understanding subtle and/or complex crystallization behavior. The aim of the study was to investigate low-frequency Raman spectroscopy for in situ monitoring of crystallization of an amorphous pharmaceutical in slurries for the first

SUBMITTER: Koskela J 

PROVIDER: S-EPMC9257757 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature