Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function.

ABSTRACT:

Background

People with chronic kidney disease (CKD) are at high risk for cognitive impairment and progressive cognitive decline. Retention of protein-bound organic solutes that are normally removed by tubular secretion is hypothesized to contribute to cognitive impairment in CKD.

Methods

We followed 2362 participants who were initially free of cognitive impairment and stroke in the prospective Chronic Renal Insufficiency Cohort (CRIC) Study. We estimated tubular secretory clearance by the 24-hour kidney clearances of eight endogenous solutes that are primarily eliminated by tubular secretion. CRIC study investigators assessed participants' cognitive function annually using the Modified Mini-Mental State (3MS) Examination. Cognitive decline was defined as a sustained decrease

SUBMITTER: Lidgard B 

PROVIDER: S-EPMC9257801 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature