Strain Specific Variations in <i>Acinetobacter baumannii</i> Complement Sensitivity.

ABSTRACT: The complement system is required for innate immunity against Acinetobacter baumannii, an important cause of antibiotic resistant systemic infections. A. baumannii strains differ in their susceptibility to the membrane attack complex (MAC) formed from terminal complement pathway proteins, but the reasons for this variation remain poorly understood. We have characterized in detail the complement sensitivity phenotypes of nine A. baumannii clinical strains and some of the factors that might influence differences between strains. Using A. baumannii laboratory strains and flow cytometry assays, we first reconfirmed that both opsonization with the complement proteins C3b/iC3b and MAC formation were inhibited by the capsule. There were marked differences in C3b/iC3b a

SUBMITTER: Kamuyu G 

PROVIDER: S-EPMC9258041 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature