Effects of the increased protein level in small intestine on the colonic microbiota, inflammation and barrier function in growing pigs.

ABSTRACT:

Background

An increased level of the dietary protein alters the colonic microbial community and metabolic profile of pigs, but it remains unclear whether this leads to colonic inflammation and impairs barrier function in growing pigs.

Results

Sixteen pigs (35.2 ± 0.3 kg) were infused with sterile saline (control) or soy protein hydrolysate (SPH) (70 g/day) through a duodenal fistula twice daily during a 15-day experimental period. The SPH treatment did not affect their average daily feed intake and daily weight gain (P > 0.05), but reduced colon index and length (P < 0.05). Illumina MiSeq sequencing revealed that species richness was increased following SPH intervention (P < 0.05). Furthermore, SPH reduced the abundance of butyrate- and propionate-producing bacteria-such as

SUBMITTER: Li Z 

PROVIDER: S-EPMC9258065 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature