Syringin exerts anti-breast cancer effects through PI3K-AKT and EGFR-RAS-RAF pathways.

ABSTRACT:

Background

Breast cancer (BC) is one of the most common malignant tumors with the highest mortality in the world. Modern pharmacological studies have shown that Syringin has an inhibitory effect on many tumors, but its anti-BC efficacy and mechanism are still unclear.

Methods

First, Syringin was isolated from Acanthopanax senticosus (Rupr. & Maxim.) Harms (ASH) by systematic solvent extraction and silica gel chromatography column. The plant name is composed of genus epithet, species additive words and the persons' name who give its name. Then, the hub targets of Syringin against BC were revealed by bioinformatics. To provide a more experimental basis for later research, the hub genes which could be candidate biomarkers of BC and a ceRNA network related to them were obtained.

SUBMITTER: Wang F 

PROVIDER: S-EPMC9258109 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature