Grape seed and skin extract, a potential prebiotic with anti-obesity effect through gut microbiota modulation.

ABSTRACT:

Background

Obesity is a worldwide health problem and a significant risk factor for diabetes and cardiovascular diseases. Gut microbiota (GM) plays an essential role in obesity, and prebiotics such as polyphenols could be one way to improve microbial dysbiosis-induced obesity.

Objective

This study was designed to assess the effectiveness of grape seed and skin extract (GSSE), and/or orlistat on obese rats fed with high fat diet by targeting GM modulations. The impact of treatments was also studied in non-obese rats.

Material and methods

Rats were rendered obese or kept with a standard diet for three months. Then they were treated either with GSSE or orlistat or with the combined treatment (GSOR) during three months and then sacrificed. Adipose tissues, blood and faeces

SUBMITTER: Mokrani M 

PROVIDER: S-EPMC9258160 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature