Identification of functional pathways and molecular signatures in neuroendocrine neoplasms by multi-omics analysis.

ABSTRACT:

Background

Neuroendocrine neoplasms (NENs) represent a heterogeneous class of rare tumors with increasing incidence. They are characterized by the ability to secrete peptide hormones and biogenic amines but other reliable biomarkers are lacking, making diagnosis and identification of the primary site very challenging. While in some NENs, such as the pancreatic ones, next generation sequencing technologies allowed the identification of new molecular hallmarks, our knowledge of the molecular profile of NENs from other anatomical sites is still poor.

Methods

Starting from the concept that NENs from different organs may be clinically and genetically correlated, we applied a multi-omics approach by combining multigene panel testing, CGH-array, transcriptome and miRNome profiling

SUBMITTER: Melone V 

PROVIDER: S-EPMC9258165 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature