Low frequency vibrating magnetic field-triggered magnetic microspheres with a nanoflagellum-like surface for cancer therapy.

ABSTRACT:

Background

The magneto-mechanical force killing cancer cells is an interesting and important strategy for cancer therapy.

Results

Novel magnetic microspheres composed of a Fe₃O₄ nanocore, a bovine serum albumin (BSA) matrix, and a rod-like SiO₂ nanoshell, which had flagellum-like surface for force-mediated cancer therapy were developed. One such magnetic microsphere (Fe₃O₄/BSA/rSiO₂) at a cancer cell (not leave the cell surface) under a low frequency vibrating magnetic field (VMF) could generate 6.17 pN force. Interestingly, this force could induce cancer cell to generate reactive oxygen species (ROS). The force and force-induced ROS could kill cancer cells. The cell killing efficiency of Fe₃O₄

SUBMITTER: Guo Y 

PROVIDER: S-EPMC9258173 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature