Sensitization to peanut, egg or pets is associated with skin barrier dysfunction in children with atopic dermatitis.

ABSTRACT:

Background

Children with atopic dermatitis (AD) are often sensitized to food and aeroallergens, but sensitization patterns have not been analysed with biologic measures of disease pathogenicity.

Objective

We sought to define allergen sensitization grouping(s) using unbiased machine learning and determine their associations with skin filaggrin (FLG) and transepidermal water loss (TEWL) (assesses skin barrier integrity), S100A8 and S100A9 expression (assesses skin inflammation) and AD severity.

Methods

We studied 400 children with AD in the Mechanisms of Progression from Atopic Dermatitis to Asthma in Children (MPAACH) cohort to identify groupings of food and aeroallergen sensitizations. MPAACH is a paediatric AD cohort, aged 1-2, recruited through hospital/community se

SUBMITTER: Sherenian MG 

PROVIDER: S-EPMC9258184 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature