The longitudinal bidirectional relationship between autistic traits and brain morphology from childhood to adolescence: a population-based cohort study.

ABSTRACT:

Objective

Autistic traits are associated with alterations in brain morphology. However, the anatomic location of these differences and their developmental trajectories are unclear. The primary objective of this longitudinal study was to explore the bidirectional relationship between autistic traits and brain morphology from childhood to adolescence.

Method

Participants were drawn from a population-based cohort. Cross-sectional and longitudinal analyses included 1950 (mean age 13.5) and 304 participants (mean ages 6.2 and 13.5), respectively. Autistic traits were measured with the Social Responsiveness Scale. Global brain measures and surface-based measures of gyrification, cortical thickness and surface area were obtained from T₁-weighted MRI scans. Cross-sectiona

SUBMITTER: Durkut M 

PROVIDER: S-EPMC9258195 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature