IGF1 receptor-targeted black TiO₂ nanoprobes for MRI-guided synergetic photothermal-chemotherapy in drug resistant pancreatic tumor.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignant tumors with features of matrix barrier caused poor drug permeability, and susceptibility to drug resistance. Herein, a PDAC and its stromal cell dual-targeted photothermal-chemotherapy strategy is explored to loosen the matrix and reverse drug resistance. To achieve this goal, black TiO₂-Gd nanocomposites were conjugated with insulin like growth factor 1 (IGF1), and loaded with gemcitabine (GEM) to construct bTiO₂-Gd-IGF1-GEM nanoprobes. In vitro results show that under 808 nm near-infrared irradiation, killing effect of the nanoprobes on drug-resistant MIA PaCa-2 cell is 3.3 times than that of GEM alone. In vivo experiments indicate the synergetic photothermal-chemotherapy not only loosens fibro

SUBMITTER: Xu K 

PROVIDER: S-EPMC9258211 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature