Assessment of sublingual microcirculation for the screening of diabetic nephropathy.

ABSTRACT:

Objective

To investigate the potential of employing sublingual microcirculation as an early noninvasive screening technique for diabetic nephropathy (DN).

Research design and methods

We recruited 89 patients with type 2 diabetes mellitus (T2DM) and 41 healthy subjects in this cross-sectional observational study. All participants underwent fluorescein fundus angiography, vibration perception testing, 10 g (Semmes-Weinstein) monofilament examination, nerve conduction velocity, and 24-h urine microalbumin determination. HbA1c, fasting plasma glucose, blood lipid, and estimated glomerular filtration rate(eGFR) were measured. Sublingual microcirculatory images were captured using side-stream dark-field (SDF) microcirculation microscopy, and total and perfused vascular density (TV

SUBMITTER: Li Q 

PROVIDER: S-EPMC9258215 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature