Coacervation of poly-electrolytes in the presence of lipid bilayers: mutual alteration of structure and morphology.

ABSTRACT: Many intrinsically disordered peptides have been shown to undergo liquid-liquid phase separation and form complex coacervates, which play various regulatory roles in the cell. Recent experimental studies found that such phase separation processes may also occur at the lipid membrane surface and help organize biomolecules during signaling events; in some cases, phase separation of proteins at the membrane surface was also observed to lead to significant remodeling of the membrane morphology. The molecular mechanisms that govern the interactions between complex coacervates and lipid membranes and the impacts of such interactions on their structure and morphology, however, remain unclear. Here we study the coacervation of poly-glutamate (E₃₀) and poly-lysine (K₃₀) in the

SUBMITTER: Mondal S 

PROVIDER: S-EPMC9258347 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature