Phase II study of ceralasertib (AZD6738) in combination with durvalumab in patients with advanced gastric cancer.

ABSTRACT:

Background

Targeting the DNA damage repair (DDR) pathways is an attractive strategy for boosting cancer immunotherapy. Ceralasertib (AZD6738) is an oral kinase inhibitor of ataxia telangiectasia and Rad3 related protein, which is a master regulator of DDR. We conducted a phase II trial of ceralasertib plus durvalumab in patients with previously treated advanced gastric cancer (AGC) to demonstrate the safety, tolerability, and clinical activity of the combination.

Methods

This phase II, open-label, single-center, non-randomized study was designed to evaluate the efficacy and safety of ceralasertib in combination with durvalumab in patients with AGC. The study drug regimen was ceralasertib (240 mg two times a day) days 15-28 in a 28-day cycle in combination with durvalumab (15

SUBMITTER: Kwon M 

PROVIDER: S-EPMC9258491 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature