Evaluating the power and limitations of genome-wide association studies in Caenorhabditis elegans.

ABSTRACT: Quantitative genetics in Caenorhabditis elegans seeks to identify naturally segregating genetic variants that underlie complex traits. Genome-wide association studies scan the genome for individual genetic variants that are significantly correlated with phenotypic variation in a population, or quantitative trait loci. Genome-wide association studies are a popular choice for quantitative genetic analyses because the quantitative trait loci that are discovered segregate in natural populations. Despite numerous successful mapping experiments, the empirical performance of genome-wide association study has not, to date, been formally evaluated in C. elegans. We developed an open-source genome-wide association study pipeline called NemaScan and used a simulation-based approach to provide benchma

SUBMITTER: Widmayer SJ 

PROVIDER: S-EPMC9258552 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature