Association between VDR Gene Polymorphisms and Melanoma Susceptibility in a Colombian Population.

ABSTRACT:

Background

The vitamin D receptor (VDR) is responsible for mediating the effects of vitamin D through regulation of other gene transcriptions. There are several polymorphisms that alter the gene expression or the function of this protein. We aimed to analyze the association between two SNPs  of VDR gene and melanoma cancer in Colombian patients.

Methods

We included 120 healthy individual as controls and 120 melanoma cancer patients as cases . Patients in both groups were matched in terms of gender and age. The genotyping of rs731236 and rs2228570 polymorphisms was performed using PCR-RFLP. The SNPStats program was used to carry out the statistical analysis through a logistic regression model.

Results

Under dominant model, we found that rs2228570 polymorphism was assoc

SUBMITTER: Aristizabal-Pachon AF 

PROVIDER: S-EPMC9258646 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature