Iron oxide nanoparticles with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy.

ABSTRACT: Metal-based nanomaterials usually have broad-spectrum antibacterial properties, low biological toxicity and no drug resistance due to their intrinsic enzyme-like catalytic properties and external field (magnetic, thermal, acoustic, optical and electrical) responsiveness. Herein, iron oxide (Fe₃O₄) nanoparticles (IONPs) synthesized by us have good biosafety, excellent photothermal conversion ability and peroxidase-like catalytic activity, which can be used to construct a photothermal-enzymes combined antibacterial treatment platform. IONPs with peroxide-like catalytic activity can induce H₂O₂ to catalyze the production of •OH in a slightly acidic environment, thus achieving certain bactericidal effects and increasing the sensitivity of bacteria to

SUBMITTER: Guo J 

PROVIDER: S-EPMC9258688 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature