Ontology highlight
ABSTRACT:
SUBMITTER: Zhang HZ
PROVIDER: S-EPMC9258703 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Zhang Hong Zhe HZ Han Seongho S Kim Sung-Whan SW
Journal of cellular and molecular medicine 20220526 13
Although stem cells have extensively been studied as a novel vehicle for tissue repair, their sustained efficacy remains controversial. In this study, we aimed to investigate the angiogenic potency over time of stromal cell-derived factor-1 (SDF-1) gene-edited amniotic mesenchymal stem cells (AMM/S) in a hindlimb ischaemia model. An SDF-1 transgene was inserted into the AMM cell genome via transcription activator-like effector nuclease (TALEN) mediated knock-in, and cell migration, Matrigel tube ...[more]