Estimated Glomerular Filtration Rate Variability in Patients With Heart Failure and Chronic Kidney Disease.

ABSTRACT:

Background

Greater variability in the estimated glomerular filtration rate (eGFR) is associated with higher mortality in patients with chronic kidney disease (CKD). Heart failure (HF) is common in CKD and may increase variability through changes in hemodynamic and volume regulation. We sought to determine if patients with vs without HF have higher kidney function variability in CKD, and to define the association with mortality.

Methods and results

Patients undergoing coronary angiography from 2003 to 2013 with an eGFR of less than 60 mL/min/1.73 m² were evaluated from the Duke Databank for Cardiovascular Disease. Variability in the eGFR, measured as the coefficient of variation (CV) of residuals from the regression of eGFR vs time, was calculated spanning 3 months

SUBMITTER: Hein AM 

PROVIDER: S-EPMC9258722 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature