Vitamin D and SARS-CoV2 infection, severity and mortality: A systematic review and meta-analysis.

ABSTRACT: To assess the evidence on SARS-CoV2 infection and Covid-19 in relation to deficiency and supplementation of vitamin D, we conducted a systematic review up to April 2021. We summarised data from 38 eligible studies, which presented risk estimates for at least one endpoint, including two RCT and 27 cohort-studies: 205565 patients with information on 25OHD status and 2022 taking vitamin D supplementation with a total of 1197 admitted to the ICU or who needed invasive mechanical ventilation or intubation and hospital stay, and more than 910 Covid-19 deaths. Primary outcomes were severity and mortality and the main aim was to evaluate the association with vitamin D supplementation. Random effects models showed that supplementation was associated with a significant lower risk of both Covid-19 se

SUBMITTER: D'Ecclesiis O 

PROVIDER: S-EPMC9258852 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature