Pseudomonas aeruginosa clinical blood isolates display significant phenotypic variability.

ABSTRACT: Pseudomonas aeruginosa is a significant threat in healthcare settings where it deploys a wide host of virulence factors to cause disease. Many virulence-related phenotypes such as pyocyanin production, biofilm formation, and twitching motility have been implicated in causing disease in a number of hosts. In this study, we investigate these three virulence factors in a collection of 22 clinical strains isolated from blood stream infections. Despite the fact that all 22 strains caused disease and came from the same body site of different patients, they show significant variability in assays for each of the three specific phenotypes examined. There was no significant correlation between the strength of the three phenotypes across our collection, suggesting that they can be independently modul

SUBMITTER: Scheffler RJ 

PROVIDER: S-EPMC9258867 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature