Modeling cortical synaptic effects of anesthesia and their cholinergic reversal.

ABSTRACT: General anesthetics work through a variety of molecular mechanisms while resulting in the common end point of sedation and loss of consciousness. Generally, the administration of common anesthetics induces reduction in synaptic excitation while promoting synaptic inhibition. Exogenous modulation of the anesthetics' synaptic effects can help determine the neuronal pathways involved in anesthesia. For example, both animal and human studies have shown that exogenously induced increases in acetylcholine in the brain can elicit wakeful-like behavior despite the continued presence of the anesthetic. However, the underlying mechanisms of anesthesia reversal at the cellular level have not been investigated. Here we apply a computational model of a network of excitatory and inhibitory neurons to si

SUBMITTER: Eniwaye BP 

PROVIDER: S-EPMC9258872 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature