BATF regulates progenitor to cytolytic effector CD8⁺ T cell transition during chronic viral infection.

ABSTRACT: During chronic viral infection, CD8⁺ T cells develop into three major phenotypically and functionally distinct subsets: Ly108⁺TCF-1⁺ progenitors, Ly108^-CX₃CR1^- terminally exhausted cells and the recently identified CX₃CR1⁺ cytotoxic effector cells. Nevertheless, how CX₃CR1⁺ effector cell differentiation is transcriptionally and epigenetically regulated remains elusive. Here, we identify distinct gene regulatory networks and epigenetic landscapes underpinning the formation of these subsets. Notably, our data demonstrate that CX₃CR1⁺ effector cells bear a striking similarity to short-lived effector cells during acute infection. Genetic deletion of Tbx21 signific

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9258987 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature