Potential value of PRKDC as a therapeutic target and prognostic biomarker in pan-cancer.

ABSTRACT:

Background

While protein kinase, DNA-activated, catalytic subunit (PRKDC) plays an important role in double-strand break repair to retain genomic stability, there is still no pan-cancer analysis based on large clinical information on the relationship between PRKDC and different tumors. For the first time, this research used numerous databases to perform a pan-cancer review for PRKDC to explore the possible mechanism of PRKDC in the etiology and outcomes in various tumors.

Methods

PRKDC's expression profile and prognostic significance in pan-cancer were investigated based on various databases and online platforms, including TIMER2, GEPIA2, cBioPortal, CPTAC, and SangerBox. We applied the TIMER to identified the interlink of PRKDC and the immune infiltration in assorted tumors

SUBMITTER: Yang X 

PROVIDER: S-EPMC9259106 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature