Plasma exchange treats severe intrahepatic cholestasis caused by dacomitinib: A case report.

ABSTRACT:

Rationale

Dacomitinib-induced liver injury is often manifested by mild elevations of transaminases and bilirubin, and severe intrahepatic cholestasis caused by dacomitinib for simultaneous taking orally cytochrome P450 2D6 (CYP2D6) competitive substrates has been rarely reported.

Patient concerns

The patient was a 69-year-old woman with non-small cell lung cancer (NSCLC) who was prescribed oral dacomitinib for a month; she was given oral loratadine due to "allergic rhinitis" and metoprolol extended action tablets due to "tachycardia" separately for a few days during the course of dacomitinib treatment. The patient developed liver damage, increased fatigue, yellow urine, and pruritus, with significantly elevated serum levels of bilirubin and glutamyltranspetidase.

Diagnosi

SUBMITTER: Qiao F 

PROVIDER: S-EPMC9259143 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature