Chemokines in ICU Delirium: An Exploratory Study.

ABSTRACT:

Objectives

The pathophysiology of delirium is complex and incompletely understood. Inflammation is hypothesized to be integral to its development due to effects on blood brain barrier integrity, facilitation of leukocyte extravasation into brain parenchyma, and propagation of neuroinflammation. Septic shock is the prototypical condition associated with ICU delirium; however, the relative contribution of resultant hypotension and systemic inflammation to the development of delirium is unknown.

Design

This was a prospective exploratory study.

Setting

A multidisciplinary ICU at an academic medical center in Phoenix, AZ.

Patients

Critically ill patients older than or equal to 18 years old admitted to the ICU.

Interventions

None.

Measurements and main resu

SUBMITTER: Smith RJ 

PROVIDER: S-EPMC9259165 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature