Identification of Prognostic DNA Methylation Signatures in Lung Adenocarcinoma.

ABSTRACT:

Background

Increasing evidence exists of a link between DNA methylation and tumor immunotherapy. However, the impact of DNA methylation on the characteristics of the lung adenocarcinoma microenvironment and its effect on immunotherapy remain unclear.

Method

This study collected TCGA-LUAD related data sets (LUAD) to explore the characteristics and regulation of 20 DNA methylation-related genes. We further identified two DNA methylation subtypes by analysing the expression profiles of these 20 DNA methylation-related genes. Subsequently, the differences in immune cell infiltration (ICI) and the expression of immune-related signaling factors among different DNA methylation subtypes were explored, and the differentially expressed genes (DEGs) among different LUAD DNA methylation

SUBMITTER: Wang P 

PROVIDER: S-EPMC9259289 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature