Regulatory Role of miRNAs and lncRNAs in Gout.

ABSTRACT:

Objective

To explore the regulatory functions of ceRNA networks in the nosogenesis of gout and search for potential therapeutic targets.

Methods

We searched the GEO database and downloaded the lncRNA microarray chipset GSE160170. This matrix series was analyzed to yield differentially expressed lncRNAs and mRNAs. Then, the correlations between lncRNAs and miRNAs were obtained by comparing the highly conserved miRNA families. The predicted miRNA-regulating mRNAs were matched to the differentially expressed mRNAs from the chipset analyses to obtain miRNA-mRNA interactions. Next, we used the Cytoscape software to model ceRNA networks and the STRING database to determine their protein-protein interactions. The R software was used to algorithmically screen the functional pathways

SUBMITTER: Shu J 

PROVIDER: S-EPMC9259367 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature