White matter microstructure and volume correlates of premenstrual dysphoric disorder.

ABSTRACT:

Background

Premenstrual dysphoric disorder (PMDD) is a mood disorder characterized by psychological and physical symptoms. Differences in white matter have been associated with affective and anxiety disorders, which share some symptoms with PMDD. However, whether white matter structure differs between the brains of individuals with PMDD and healthy controls is not known, nor is its relation to symptom severity.

Methods

We performed tract-based spatial statistics and voxel-based morphometry analyses of diffusion tensor imaging metrics and white matter volume, using 2 neuroimaging data sets (n = 67 and n = 131) and a combined whole-brain and region-of-interest approach. We performed correlation analyses to investigate the relationship between regions with differe

SUBMITTER: Gu X 

PROVIDER: S-EPMC9259386 | biostudies-literature | 2022 Jan-Feb

REPOSITORIES: biostudies-literature