Lower fractional anisotropy of the corticothalamic tract and increased response time variability in adult patients with ADHD.

ABSTRACT:

Background

Intraindividual intertrial variability has been suggested as an endophenotype of attention-deficit/hyperactivity disorder (ADHD). It is usually evaluated as response time variability (RTV) in reaction time tasks, and RTV has emerged as a robust and stable feature of ADHD. Among attempts to elucidate the neurobiological underpinnings of RTV, it has been suggested that alterations in white matter microstructure may explain RTV.

Methods

We used diffusion tensor imaging (DTI) in a group of 53 adults with ADHD and 50 healthy controls. We obtained RTV parameters from a simple reaction-time task, in which participants were asked to respond to the appearance of white crosses on a screen using button presses.

Results

We observed significant between-group differences

SUBMITTER: Kolle M 

PROVIDER: S-EPMC9259413 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature