Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost.

ABSTRACT: The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals^1-3. Despite the reduced protection from infection, individuals who received three doses of an mRNA vaccine were highly protected from more serious consequences of infection⁴. Here we examine the memory B cell repertoire in a longitudinal cohort of individuals receiving three mRNA vaccine doses^5,6. We find that the third dose is accompanied by an increase in, and evolution of, receptor-binding domain (RBD)-specific memory B cells. The increase is due to expansion of memory B cell clones that were present after the second dose as well as the emergence of new clones. The antibodies encoded by these cells showed significantly increased potency and breadth when compared with

SUBMITTER: Muecksch F 

PROVIDER: S-EPMC9259484 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature