PIEZO1 transduces mechanical itch in mice.

ABSTRACT: Itch triggers scratching, a behavioural defence mechanism that aids in the removal of harmful irritants and parasites¹. Chemical itch is triggered by many endogenous and exogenous cues, such as pro-inflammatory histamine, which is released during an allergic reaction¹. Mechanical itch can be triggered by light sensations such as wool fibres or a crawling insect². In contrast to chemical itch pathways, which have been extensively studied, the mechanisms that underlie the transduction of mechanical itch are largely unknown. Here we show that the mechanically activated ion channel PIEZO1 (ref. ³) is selectively expressed by itch-specific sensory neurons and is required for their mechanically activated currents. Loss of PIEZO1 function in peripheral

SUBMITTER: Hill RZ 

PROVIDER: S-EPMC9259491 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature