Relationship between temporal rhythm-based classification of atrial fibrillation and stroke: real-world vs. clinical trial.

ABSTRACT:

Background

The risk of stroke according to clinical classification of atrial fibrillation (AF) remains poorly defined. Here, we assessed the impact of AF type on stroke risk in vitamin K antagonist-treated patients with AF in 'real-world' and 'clinical trial' cohorts.

Methods

Post-hoc analysis of patient-level data from the Murcia AF Project and AMADEUS trial. Clinical classification of AF was based on contemporary recommendations from international guidelines. Study endpoint was the incidence rate of ischaemic stroke. Stroke risk was determined using CHA₂DS₂-VASc score and CARS. A modified CHA₂DS₂-VAS'c' score that applied one additional point for a 'c' criterion of continuous AF (i.e. non-paroxysmal AF) was calculated.

Results

SUBMITTER: Ding WY 

PROVIDER: S-EPMC9259516 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature