The Two Sides of Siponimod: Evidence for Brain and Immune Mechanisms in Multiple Sclerosis.

ABSTRACT: Siponimod is a selective sphingosine 1-phosphate receptor subtype 1 (S1P₁) and 5 (S1P₅) modulator approved in the United States and the European Union as an oral treatment for adults with relapsing forms of multiple sclerosis (RMS), including active secondary progressive multiple sclerosis (SPMS). Preclinical and clinical studies provide support for a dual mechanism of action of siponimod, targeting peripherally mediated inflammation and exerting direct central effects. As an S1P₁ receptor modulator, siponimod reduces lymphocyte egress from lymph nodes, thus inhibiting their migration from the periphery to the central nervous system. As a result of its peripheral immunomodulatory effects, siponimod reduces both magnetic resonance imaging (MRI) lesion (gadol

SUBMITTER: Cohan SL 

PROVIDER: S-EPMC9259525 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature