A structural homology approach to identify potential cross-reactive antibody responses following SARS-CoV-2 infection.

ABSTRACT: The emergence of the novel SARS-CoV-2 virus is the most important public-health issue of our time. Understanding the diverse clinical presentations of the ensuing disease, COVID-19, remains a critical unmet need. Here we present a comprehensive listing of the diverse clinical indications associated with COVID-19. We explore the theory that anti-SARS-CoV-2 antibodies could cross-react with endogenous human proteins driving some of the pathologies associated with COVID-19. We describe a novel computational approach to estimate structural homology between SARS-CoV-2 proteins and human proteins. Antibodies are more likely to interrogate 3D-structural epitopes than continuous linear epitopes. This computational workflow identified 346 human proteins containing a domain with high structural homo

SUBMITTER: McGill JR 

PROVIDER: S-EPMC9259575 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature