Early retinal functional alteration in relation to diabetes duration in patients with type 2 diabetes without diabetic retinopathy.

ABSTRACT: To examine the retinal structure and function in relation to diabetes duration and glycemia in patients without diabetic retinopathy (DR). 85 adults with type 2 diabetes without DR or macular edema underwent dilated indirect ophthalmoscopy, optical coherence tomography (OCT), ultra-wide field fundus photography, multifocal electroretinography (mfERG) and HbA_1C assessment. Patients were stratified as those with diabetes duration < 10 years and ≥ 10 years. Right eyes of all participants were analyzed. mfERG was analysed as ring 12, 34, 56. No significant differences were noted in OCT-derived retinal thickness measures between groups. mfERG P1 latencies were delayed, and amplitudes (nV/deg²) were reduced in all three rings in those with diabetes duration ≥ 10 years vs. <

SUBMITTER: Srinivasan S 

PROVIDER: S-EPMC9259684 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature