Deep Learning-Based Multi-Omics Integration Robustly Predicts Relapse in Prostate Cancer.

ABSTRACT:

Objective

Post-operative biochemical relapse (BCR) continues to occur in a significant percentage of patients with localized prostate cancer (PCa). Current stratification methods are not adequate to identify high-risk patients. The present study exploits the ability of deep learning (DL) algorithms using the H2O package to combine multi-omics data to resolve this problem.

Methods

Five-omics data from 417 PCa patients from The Cancer Genome Atlas (TCGA) were used to construct the DL-based, relapse-sensitive model. Among them, 265 (63.5%) individuals experienced BCR. Five additional independent validation sets were applied to assess its predictive robustness. Bioinformatics analyses of two relapse-associated subgroups were then performed for identification of differentially ex

SUBMITTER: Wei Z 

PROVIDER: S-EPMC9259796 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature