Modulation of Cellular Circadian Rhythms by Secondary Metabolites of Lichens.

ABSTRACT:

Background

Most mammalian cells harbor molecular circadian clocks that synchronize physiological functions with the 24-h day-night cycle. Disruption of circadian rhythms, through genetic or environmental changes, promotes the development of disorders like obesity, cardiovascular diseases, and cancer. At the cellular level, circadian, mitotic, and redox cycles are functionally coupled. Evernic (EA) and usnic acid (UA), two lichen secondary metabolites, show various pharmacological activities including anti-oxidative, anti-inflammatory, and neuroprotective action. All these effects have likewise been associated with a functional circadian clock.

Hypothesis/purpose

To test, if the lichen compounds EA and UA modulate circadian clock function at the cellular level.

Methods

SUBMITTER: Srimani S 

PROVIDER: S-EPMC9260025 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature